I am not sure why it took me so long to implement, but I finally had it with the Vibrant Media IntelliTXT in-line text advertising and their intrusive pop-ups. You have probably seen them yourself. They are the highlighted green words with a double underscore present in many news and blog pages. While they generate money for those sites, they are as irritating as hell, so I decided to remove them.
I opened a web page which I knew would display the Vibrant advertising. A few seconds after the page displayed, the green meanies appeared. That indicated a remote Java script. Viewing the page source HTML, down at the bottom was a pretty clear text comment: "start Vibrant Media IntelliTXT script section". Target found. Well, that was easy.
The script source link was to the IntelliTXT web site, so it was clear that blocking that web site would stop the green meanies. I use IE8, so I went to the Internet Options, Security tab, Restricted sites zone icon, Sites button. I added the following to the restricted sites list: *.us.intellitxt.com. While I was at it, I also included *.tacoda.net to block their behavioral tracking.
Do it yourself for free.
Note: I know there are many add-ins which will do this for you. I try to run the computers in our house with a minimum of software which needs regular updates.
Update: I also added *.kontera.com to block their "blue meanie" popup ads.